Streptomycin and Tuberculous Meningitis

Streptomycin in Tuberculous Meningitis

Tuberculous meningitis is universally considered to be a fatal disease. Examples of spontaneous recovery have been reported, but they are rare and complete laboratory confirmation in most of these is lacking. In January, 1944, Schatz, Bugie, and Waksman2 reported the isolation of streptomycin. In November, 1944, Schatz and Waksmat3 demonstrated its marked bacteriostatic and bactericidal action ...

The streptomycin treatment of tuberculous meningitis.

Streptomycin is the antibiotic principle prepared from Streptomyces griseus, and it is active against a wide range of bacteria. Its chief interest lies in its activity against M. tuberculosis. The scarcity of streptomycin in this country has led in the main to its use only in conditions for which no other form of treatment 1s available, and of these conditions in children tuberculous meningitis...

Treatment of tuberculous meningitis with streptomycin.

Tuberculous meningitis treated with streptomycin and isoniazid without intrathecal therapy.

Isoniazid given orally readily and rapidly diffuses into the cerebrospinal fluid in health and disease (Fletcher, I952, 1953) and probably, also, gains access to tubercle bacilli within the cells. Adequate bacterio-static level of the isoniazid in the cerebrospinal fluid was found in both lower and higher doses. Throughout the illness Ritchie (I953) showed that isoniazid is more diffusible in t...

Streptomycin in tuberculous meningitis; report of a case.

under critical observation at the present time. The advent of this new drug was greeted with much enthusiasm but further clinical experience on a greater number and variety of cases has led to better appreciation of its merits and dangers. It is true that in most cases of tuberculous meningitis the immediate effects of streptomycin therapy have been so striking as to promise hope of recovery. O...